Anàlisi mitjançant modelització integrada hidràulic-hidrològica de l’estabilitat de solucions de restauració geomorfològica dissenyades amb el mètode GeoFluv

Les restauracions geomorfològiques són una tècnica força nova per a la restauració de mines a cel obert, amb un objectiu molt clar d’estabilitat davant l’erosió a llarg termini. Resulta de gran interès combinar l’ús de mètodes i softwares usats per generar dissenys de restauracions d’aquest tipus, com podria ser el Geofluv – Natural Regrade, amb models d’erosió del sòl que ajudarien a assegurar que les solucions dissenyades són estables a llarg termini. En aquest treball s’estudia la possibilitat de fer servir el model numèric Iber com a complement de Geofluv-Natural Regrade en el disseny de restauracions de mines. Per fer-ho, s’han simulat un total de tres pluges de disseny (de 2, 5 i 100 anys) per veure les tendències erosives d’una restauració feta a la mina del Machorro, al Parc Natural de l’Alto Tajo, i s’han comparat amb les erosions reals de la zona esmentada, calculades a partir de la diferència dels models d’elevació del terreny dels anys 2012 a 2018. Els mapes d’erosió obtinguts per a les tres pluges mostren una bona aproximació a la realitat del canal principal: les màximes erosions es donen en el seu tram final i a una part del tram central. En canvi, els canals secundaris on l’erosió és menor es troben millor representats amb la pluja de menor període de retorn. Tot i que caldrien estudis més complexos, d’aquesta primera aproximació fet amb Iber es pot concloure que aquest mostra un gran potencial a l’hora d’usar-se com a complement per al disseny de restauracions geomorfològiques.Las restauraciones geomorfológicas son una técnica bastante novedosa para la restauración de minas a cielo abierto, con un objetivo muy claro de estabilidad ante la erosión a largo plazo. Resulta de gran interés combinar el uso de métodos y software usados para generar diseños de restauraciones de este tipo, como podría ser el Geofluv – Natural Regrade, con modelos de erosión del suelo que ayudarían a asegurar que las soluciones diseñadas son estables en largo plazo. En este trabajo se estudia la posibilidad de utilizar el modelo numérico Iber como complemento de Geofluv-Natural Regrade en el diseño de restauraciones de minas. Para ello, se han simulado un total de tres lluvias de diseño (de 2, 5 y 100 años) para ver las tendencias erosivas de una restauración hecha en la mina del Machorro, en el Parque Natural del Alto Tajo, y se han comparado con las erosiones reales de dicha zona, calculadas a partir de la diferencia de los modelos de elevación del terreno de los años 2012 a 2018. Los mapas de erosión obtenidos para las tres lluvias muestran una buena aproximación a la realidad del canal principal: las máximas erosiones se dan en su tramo final y en una parte del tramo central. En cambio, los canales secundarios donde la erosión es menor se encuentran mejor representados con la lluvia de menor período de retorno. Aunque se necesitarían estudios más complejos, de esta primera aproximación realizada con Iber se puede concluir que éste muestra un gran potencial a la hora de usarse como complemento para el diseño de restauraciones geomorfológicas.Geomorphic reclamation is a very new technique for the restoration of open-cut mines, with a very clear objective of long-term stabilisation against erosion. It is of great interest to combine the use of methods and software used to generate restoration designs of this type, such as Geofluv - Natural Regrade, with soil erosion models that would help to ensure that the solutions designed are long-term stable. This final work studies the possibility of using the Iber numerical model as a complement to Geofluv-Natural Regrade in the design of mine reclamation. To do so, a total of three design rains (of 2, 5 and 100 years of return period) have been simulated to see the erosion trends of a restoration carried out in the Machorro mine, in the Alto Tajo Natural Park, and compared with the real erosion of the area, calculated from the difference in the elevation models of the land from 2012 to 2018. The erosion maps obtained for the three cases show a good approximation to the reality of the main channel: the maximum erosion occurs in the final section and in part of the central section. In contrast, the secondary channels where erosion is less severe are better represented with the lightest rain. Although more complex studies are needed, it can be concluded from this first approximation made with Iber that it shows great potential for use as a complement to the design of geomorphological restorations

Análisis económico-financiero de Certest Biotec S.L.

Certest Biotec S.L. es una empresa biotecnológica zaragozana dedicada a lainvestigación, producción y desarrollo de productos para el diagnóstico in vitro enmuestras humanas.En este proyecto analizaremos la situación económico-financiera de Certest en elperiodo que transcurre del año 2011 hasta el año 2018. Para ello se emplearan una seriede técnicas que nos permitan llegar a una conclusión sobre la situación, evolución ytendencia de Certest y sus competidoras: Genomica S.A., Vircell S.L. y Operon S.A.Para concluir, utilizaremos el modelo Altman Z-Score para predecir las posibilidades dequiebra de Certest establecida por una combinación de determinados ratios financierosque más adelante interpretaremos.Palabras clave: Certest, análisis económico-financiero, sector biotecnológico, modeloZ-Score.<br /

Estudio para la mejora de la calidad del grado en Trabajo Social en atención a las necesidades de nuestros egresados y sus empleadores

Mediante este proyecto la Facultad de Trabajo Social de la UCM pretende conocer cuáles son las necesidades formativas de nuestros alumnos con el principal objetivo de hacer una modificación en la titulación que pueda dar respuesta a las necesidades de conocimiento de nuestros profesionales así como conocer las condiciones esenciales en las que nuestros egresado acceden al mercado laboral

Diagnostico del Impacto del Palangre de Fondo en los Hábitats Bentónicos en los LICs de la RN20000

En prens

Long-term follow-up of certolizumab pegol in uveitis due to immune-mediated inflammatory diseases : multicentre study of 80 patients

Objectives To evaluate effectiveness and safety of certolizumab pegol (CZP) in uveitis due to immune-mediated inflammatory diseases (IMID). Methods Multicentre study of CZP-treated patients with IMID uveitis refractory to conventional immunosuppressant. Effectiveness was assessed through the following ocular parameters: best-corrected visual acuity, anterior chamber cells, vitritis, macular thickness and retinal vasculitis. These variables were compared between the baseline, and first week, first, third, sixth months, first and second year. Results We studied 80 (33 men/47 women) patients (111 affected eyes) with a mean age of 41.6±11.7 years. The IMID included were: spondyloarthritis (n=43), Behçet's disease (n=10), psoriatic arthritis (n=8), Crohn's disease (n=4), sarcoidosis (n=2), juvenile idiopathic arthritis (n=1), reactive arthritis (n=1), rheumatoid arthritis (n=1), relapsing polychondritis (n=1), Conclusions CZP seems to be effective and safe in uveitis related to different IMID, even in patients refractory to previous biological drugs

El deporte femenino, ese gran desconocido

Actas de la Jornada "El deporte femenino, ese gran desconocido" celebrada el 26 de septiembre de 2018 en la Universidad Carlos III de Madrid

Investigación joven con perspectiva de género III

Actas del III Congreso Internacional de Estudios de Género, Perspectivas y Retos de Futuro: Jóvenes Investigadores (Getafe, 13 - 15 de junio de 2018) organizado por el Instituto Universitario de Estudios de Género de la Universidad Carlos III de Madrid

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe

Spatiotemporal Characteristics of the Largest HIV-1 CRF02_AG Outbreak in Spain: Evidence for Onward Transmissions

Background and Aim: The circulating recombinant form 02_AG (CRF02_AG) is the predominant clade among the human immunodeficiency virus type-1 (HIV-1) non-Bs with a prevalence of 5.97% (95% Confidence Interval-CI: 5.41–6.57%) across Spain. Our aim was to estimate the levels of regional clustering for CRF02_AG and the spatiotemporal characteristics of the largest CRF02_AG subepidemic in Spain.Methods: We studied 396 CRF02_AG sequences obtained from HIV-1 diagnosed patients during 2000–2014 from 10 autonomous communities of Spain. Phylogenetic analysis was performed on the 391 CRF02_AG sequences along with all globally sampled CRF02_AG sequences (N = 3,302) as references. Phylodynamic and phylogeographic analysis was performed to the largest CRF02_AG monophyletic cluster by a Bayesian method in BEAST v1.8.0 and by reconstructing ancestral states using the criterion of parsimony in Mesquite v3.4, respectively.Results: The HIV-1 CRF02_AG prevalence differed across Spanish autonomous communities we sampled from (p &lt; 0.001). Phylogenetic analysis revealed that 52.7% of the CRF02_AG sequences formed 56 monophyletic clusters, with a range of 2–79 sequences. The CRF02_AG regional dispersal differed across Spain (p = 0.003), as suggested by monophyletic clustering. For the largest monophyletic cluster (subepidemic) (N = 79), 49.4% of the clustered sequences originated from Madrid, while most sequences (51.9%) had been obtained from men having sex with men (MSM). Molecular clock analysis suggested that the origin (tMRCA) of the CRF02_AG subepidemic was in 2002 (median estimate; 95% Highest Posterior Density-HPD interval: 1999–2004). Additionally, we found significant clustering within the CRF02_AG subepidemic according to the ethnic origin.Conclusion: CRF02_AG has been introduced as a result of multiple introductions in Spain, following regional dispersal in several cases. We showed that CRF02_AG transmissions were mostly due to regional dispersal in Spain. The hot-spot for the largest CRF02_AG regional subepidemic in Spain was in Madrid associated with MSM transmission risk group. The existence of subepidemics suggest that several spillovers occurred from Madrid to other areas. CRF02_AG sequences from Hispanics were clustered in a separate subclade suggesting no linkage between the local and Hispanic subepidemics